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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Dionísio,Jose C (1) Leão,R.M. (1) Matias,Carlos M (1) Quinta-Ferreira,Maria Emilia (1) Saggau,Peter (1) von Gersdorff,H. (1) Mais... Palavra-chave Neurotransmission (2) Calcium buffer (1) Calyx of Held (1) Capacitance measurements (1) Co-release (1) Glutamatergic (1) Inhibition (1) Mammalian auditory brainstem (1) Metabotropic fluorescence (1) Synaptic development (1) Zinc (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2014 (1) 2009 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers Biol. Res. Matias,Carlos M; Dionísio,Jose C; Saggau,Peter; Quinta-Ferreira,Maria Emilia. BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic glutamate receptors, specifically activated by DCG-IV. Previous work has shown that DCG-IV affects only mossy fiber-evoked responses but not the signals from associational-commissural afferents, blocking mossy fiber synaptic transmission. Since zinc is released from mossy fibers even for single stimuli and it is generally assumed to be co-released with glutamate, the aim of the work was to investigate the effect of DCG-IV on mossy fiber zinc signals.... Tipo: Journal article Palavras-chave: Zinc; Neurotransmission; Glutamatergic; Co-release; Metabotropic fluorescence; Inhibition. Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100067 Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held BJMBR Leão,R.M.; von Gersdorff,H.. The calyx of Held, a specialized synaptic terminal in the medial nucleus of the trapezoid body, undergoes a series of changes during postnatal development that prepares this synapse for reliable high frequency firing. These changes reduce short-term synaptic depression during tetanic stimulation and thereby prevent action potential failures during a stimulus train. We measured presynaptic membrane capacitance changes in calyces from young postnatal day 5-7 (p5-7) or older (p10-12) rat pups to examine the effect of calcium buffer capacity on vesicle pool size and the efficiency of exocytosis. Vesicle pool size was sensitive to the choice and concentration of exogenous Ca2+ buffer, and this sensitivity was much stronger in younger animals. Pool size and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calyx of Held; Neurotransmission; Calcium buffer; Capacitance measurements; Mammalian auditory brainstem; Synaptic development. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100014 Registros recuperados: 2 Primeira ... 1 ... Última

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